Abstract
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic.
Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum
sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an
inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that
vaccination mimicked an infection.
Elenalan 發表於 22-9-14 00:30
Abstract
Large-scale COVID-19 vaccinations are currently underway in many countries in response to t ...
Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells
(PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many
different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary.
Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were
confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating
symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical
conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
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